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Process synthesis with simultaneous consideration of inherent safety-inherent risk footprint

Andreja Nemet, Jiří J. Klemeš, Zdravko Kravanja

《化学科学与工程前沿（英文）》 2018年第12卷第4期页码 745-762 doi: 10.1007/s11705-018-1779-7

摘要：

Process plants should be designed to be economically viable and environmentally friendly, while also being operable and maintainable during process implementation. The safety of processes is among the most important considerations in obtaining results that are more acceptably realistic, as it is linked to the availability and reliability of the process. Inherent safety can effectively be enhanced in the early stages of the design, when the main decisions on process design are made. The aim of this study is to enhance and select the appropriate risk assessment method and to incorporate it into process synthesis, using a mathematical programming approach. A mixed-integer, nonlinear programming (MINLP) model was used for the synthesis of a methanol production process, considering risk assessment during the synthesis. Risk assessment is performed simultaneously with the MINLP process synthesis, where the risk is determined either for the whole process as overall risk, or on a per unit-of-a-product basis. For the latter, a new measurement is proposed: the inherent risk footprint. The results of a case study led to two main conclusions: (i) Significantly safer designs can be obtained at negligible economic expense, and (ii) at higher production capacities, a lower inherent risk footprint can be achieved. The results also indicate that designs obtained using this method can have significantly increased inherent safety, while remaining economically viable.

关键词： inherent safety process design simultaneous risk assessment risk footprint methanol process

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基于本质安全的工业事故风险管理方法研究

吴宗之

《中国工程科学》 2007年第9卷第5期页码 46-49

摘要：

从风险管理角度对生产过程中的安全防护方法进行了分类和论述，提出了基于本质安全思想的工业事故综合风险管理方法与程序，其核心内容是在常规的危险辨识和风险评价基础上，优先应用本质安全原理来减少、消除危险，综合采用无源安全措施、有源安全措施或多层安全防护措施与功能安全标准，将风险降低至可接受水平；提出了本质安全应与清洁生产、绿色化学、循环经济同等纳入优先发展的技术和政策等建议。

关键词：本质安全风险管理事故预防安全设计

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Genome-wide association studies: inherent limitations and future challenges

null

《医学前沿（英文）》 2012年第6卷第4期页码 444-450 doi: 10.1007/s11684-012-0225-3

摘要：

Genome-wide association studies (GWAS) have achieved great success in identifying genetic variants related to complex human diseases such as cancer and have provided valuable insights into their genetic architecture. Recently, GWAS is quite the fashion in China. However, there are issues related to its nature. Enormous work needs to be done in the post-GWAS era. Deep sequencing followed by functional studies will be needed to elucidate the underpinning biological mechanisms and further translate GWAS findings into medical practice. Along with pharmacogenomics, the success of GWAS in identifying genetic risk factors and genetic differences in drug response has been gradually enabling personalized medicine. In this article, we used hepatocellular carcinoma (HCC) as an example to demonstrate some of the inherent limitations and summarized future challenges of GWAS.

关键词： genome-wide association studies (GWAS) genetic variant cancer limitation challenge

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医院中子照射器性能与特性

李义国,夏普,彭旦,邹淑芸,吴小波,张金花, 张紫竹,高集金,王理玉,付金树,刘彤,周永茂

《中国工程科学》 2012年第14卷第8期页码 20-22

摘要：

介绍了医院中子照射器及其相关系统的设计情况，描述了医院中子照射器的性能和特性。为验证医院中子照射器的固有安全特性，进行了4.2 mk反应性释放实验。实验结果表明，反应堆功率快速上升，在229 s时，功率达到85.7 kW峰值，随后，由于燃料元件多普勒效应和慢化剂的负温度效应会非能动地把功率限制在允许的安全水平之下。满功率运行时，各个工艺房间γ剂量率小于1 μSv/h，且中子剂量率为本底水平，具有低辐射特点。

关键词：医院中子照射器硼中子俘获治疗固有安全特性

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Development and testing of a wireless smart toolholder with multi-sensor fusion

《机械工程前沿（英文）》 2023年第18卷第4期 doi: 10.1007/s11465-023-0774-y

摘要： The smart toolholder is the core component in the development of intelligent and precise manufacturing. It enables in situ monitoring of cutting data and machining accuracy evolution and has become a focal point in academic research and industrial applications. However, current table and rotational dynamometers for milling force, vibration, and temperature testing suffer from cumbersome installation and provide only a single acquisition signal, which limits their use in laboratory settings. In this study, we propose a wireless smart toolholder with multi-sensor fusion for simultaneous sensing of milling force, vibration, and temperature signals. We select force, vibration, and temperature sensors suitable for smart toolholder fusion to adapt to the cutting environment. Thereafter, structural design, circular runout, dynamic balancing, static stiffness, and dynamic inherent frequency tests are conducted to assess its dynamic and static performance. Finally, the smart toolholder is tested for accuracy and repeatability in terms of force, vibration, and temperature. Experimental results demonstrate that the smart toolholder accurately captures machining data with a relative deviation of less than 1.5% compared with existing force gauges and provides high repeatability of milling temperature and vibration signals. Therefore, it is a smart solution for machining condition monitoring.

关键词： wireless smart toolholder multi-sensor fusion circular runout dynamic balancing static stiffness dynamic inherent frequency

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Reduction of rough set attribute based on immune clone selection

LIANG Lin, XU Guang-hua

《机械工程前沿（英文）》 2006年第1卷第4期页码 413-417 doi: 10.1007/s11465-006-0049-4

摘要： A novel attribute reduction approach of rough set based on immune clone selection is proposed. In this method, the approximation quality and attribute set were adopted as evolution object and antibody, respectively. On the basis of the inherent distribution within the immune response, the global optimization of the antibody was realized through parallel local optimization. Moreover, the diversity of the antibody population was maintained with the affinity maturation and renewal of the antibody. Thus, the stable multi-optimal solutions can be preserved. In addition, the machinery fault data were analyzed by this method, and the attribute reduction sets were obtained further to satisfy the demand of feature selection in machinery diagnosis.

关键词： inherent distribution maturation evolution diversity antibody

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Numerical investigation and analysis of heat transfer enhancement in channel by longitudinal vortex based on field synergy principle

TAO Wenquan, WU Junmei

《能源前沿（英文）》 2008年第2卷第1期页码 71-78 doi: 10.1007/s11708-008-0001-x

摘要： 3-D numerical simulations were presented for laminar flow and heat transfer characteristics in a rectangular channel with vortex generators. The effects of Reynolds number (from 800 to 3 000), the attack angle of vortex generator (from 15° to 90°) and the shape of vortex generator were examined. The numerical results were analyzed based on the field synergy principle. It is found that the inherent mechanism of the heat transfer enhancement by longitudinal vortex can be explained by the field synergy principle, that is, the second flow generated by vortex generators results in the reduction of the intersection angle between the velocity and fluid temperature gradient. The longitudinal vortex improves the field synergy of the large downstream region of longitudinal vortex generator (LVG) and the region near (LVG); however, transverse vortex only improves the synergy of the region near vortex generator. Thus, longitudinal vortex can enhance the integral heat transfer of the flow field, while transverse vortex can only enhance the local heat transfer. The synergy angle decreases with the increase of Reynolds number for the channel with LVG to differ from the result obtained from the plain channel, and the triangle winglet performs better than the rectanglar one under the same surface area condition.

关键词： inherent mechanism integral surface rectanglar longitudinal

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Urban design based on public safety-Discussion on safety-based urban design

Kaizhen CAI, Jianguo WANG

《结构与土木工程前沿（英文）》 2009年第3卷第2期页码 219-227 doi: 10.1007/s11709-009-0023-4

摘要： Because of public safety problems in construction of urban surroundings, this paper expounds the necessity of the study on public safety-based urban design in perspective of modern city. It brings forward the concept of safety-based urban design and attempts to explore the basic connotation and contents with framework for studies.

关键词： urban public safety urban design safety-based urban design

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Numerical analysis on heat transfer enhancement by longitudinal vortex based on field synergy principle

WU Junmei, TAO Wenquan

《能源前沿（英文）》 2007年第1卷第3期页码 365-369 doi: 10.1007/s11708-007-0055-1

摘要： Three-dimensional numerical simulation results are presented for a fin-and-tube heat transfer surface with vortex generators. The effects of the Reynolds number (from 800 to 2 000) and the attack angle (30º and 45º) of a delta winglet vortex generator are examined. The numerical results are analyzed on the basis of the field synergy principle to explain the inherent mechanism of heat transfer enhancement by longitudinal vortex. The secondary flow generated by the vortex generators causes the reduction of the intersection angle between the velocity and fluid temperature gradients. In addition, the computational evaluations indicate that the heat transfer enhancement of delta winglet pairs for an aligned tube bank fin-and-tube surface is more significant than that for a staggered tube bank fin-and-tube surface. The heat transfer enhancement of the delta winglet pairs with an attack angle of 45º is larger than that with an angle of 30º. The delta winglet pair with an attack angle of 45º leads to an increase in pressure drop, while the delta winglet pair with the 30º angle results in a slight decrease. The heat transfer enhancement under identical pumping power condition for the attack angle of 30º is larger than that for the attack angle of 45º either for staggered or for aligned tube bank arrangement.

关键词： computational inherent mechanism staggered decrease transfer surface

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中国食品安全科技发展方向讨论

魏益民,吴永宁,周乃元,潘家荣

《中国工程科学》 2005年第7卷第11期页码 1-4

摘要：

从发展国家食品安全战略，强化国家食品安全科技的角度，提出中国食品安全科技优先发展的四大方向，即风险分析是食品安全科技战略的首选领域；“从农田到餐桌”整体控制体系是食品安全全程控制技术和操作规范的理论基础，是实施食品安全管理的重要技术手段；检测监测技术是预警、预防、应急的技术依据，应集中力量开发一批内控和标准检验必须的快速检测技术和标准检测技术；以政府、生产者、消费者为责任人主体的管理理念是食品安全管理的基本原则，食品链上的所有责任人应在保障食品质量和安全的问题上主动承担责任。

关键词：食品安全科技战略发展方向

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Probabilistic safety assessment of self-centering steel braced frame

Navid RAHGOZAR, Nima RAHGOZAR, Abdolreza S. MOGHADAM

《结构与土木工程前沿（英文）》 2018年第12卷第1期页码 163-182 doi: 10.1007/s11709-017-0384-z

摘要： The main drawback of conventional braced frames is implicitly accepting structural damage under the design earthquake load, which leads to considerable economic losses. Controlled rocking self-centering system as a modern low-damage system is capable of minimizing the drawbacks of conventional braced frames. This paper quantifies main limit states and investigates the seismic performance of self-centering braced frame using a Probabilistic Safety Assessment procedure. Margin of safety, confidence level, and mean annual frequency of the self-centering archetypes for their main limit states, including PT yield, fuse fracture, and global collapse, are established and are compared with their acceptance criteria. Considering incorporating aleatory and epistemic uncertainties, the efficiency of the system is examined. Results of the investigation indicate that the design of low- and mid-rise self-centering archetypes could provide the adequate margin of safety against exceeding the undesirable limit-states.

关键词： self-centering steel braced frame mean annual frequency safety assessment confidence level margin of safety

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安全科学若干基础问题研究

吕保和

《中国工程科学》 2006年第8卷第11期页码 57-61

摘要：

分析了安全的科学含义，引入了"灾事"的概念，指出安全科学的研究对象就是灾事，并进一步探讨了灾事的类型以及各类灾事之间的关系。阐述了构建安全科学的必要性和可行性，并从一个新的角度分析了安全科学的内涵以及构建安全科学的基本思路，论述了安全科学技术体系的层次结构。

关键词：安全灾事安全科学学科建设

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State of Practice of Construction Site Safety in the USA

Fei Dai,Yoojung Yoon,Hota V. GangaRao

《工程管理前沿（英文）》 2016年第3卷第3期页码 275-282 doi: 10.15302/J-FEM-2016035

摘要： The construction industry has long been plagued with a high number of fatalities in the USA. Much safety improvements have been made after the USA Congress passed the Occupational Safety and Health Act in 1970. However, this industry still suffers from a disproportionately high rate of work-related fatalities in comparison to other industries. To provide a holistic view of current construction safety practices and corresponding performance, this paper reviews statistics of construction fatalities and their causes. It then presents efforts led to prevent work-related accidents and injuries by the federal safety agencies and the industry. Additionally, advantages and limitations of current practices in terms of construction safety have been discussed along with promotion of aspects in construction work environment.

关键词： workplace safety construction industry safety strategy accident prevention review work

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Analyzing construction safety through time series methods

Houchen CAO, Yang Miang GOH

《工程管理前沿（英文）》 2019年第6卷第2期页码 262-274 doi: 10.1007/s42524-019-0015-6

摘要： The construction industry produces a large amount of data on a daily basis. However, existing data sets have not been fully exploited in analyzing the safety factors of construction projects. Thus, this work describes how temporal analysis techniques can be applied to improve the safety management of construction data. Various time series (TS) methods were adopted for identifying the leading indicators or predictors of construction accidents. The data set used herein was obtained from a large construction company that is based in Singapore and contains safety inspection scores, accident cases, and project-related data collected from 2008 to 2015. Five projects with complete and sufficient data for temporal analysis were selected from the data set. The filtered data set contained 23 potential leading indicators (predictors or input variables) of accidents (output or dependent variable). TS analyses were used to identify suitable accident predictors for each of the five projects. Subsequently, the selected input variables were used to develop three different TS models for predicting accident occurrences, and the vector error correction model was found to be the best model. It had the lowest root mean squared error value for three of the five projects analyzed. This study provides insights into how construction companies can utilize TS data analysis to identify projects with high risk of accidents.

关键词： time series temporal construction safety leading indicators accident prevention forecasting

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Global challenges of food safety for China

Joseph J. JEN

《农业科学与工程前沿（英文）》 2018年第5卷第3期页码 291-293 doi: 10.15302/J-FASE-2017167

摘要：

Ever since the Melamine event, China has faced challenges of food safety both domestically and globally. With the economic development, the Chinese consumers are demanding high quality, nutritious, and safe foods from the food industry but are not willing to pay higher prices. The Chinese food chain system of mostly small and medium enterprises presents challenges to the government to monitor and implement food safety laws and regulations. The academia and media are learning to take on their responsibilities with some success. Discussions and potential solutions of the global challenges of the five pillars for the food safety in China are presented here.

关键词： food safety challenges food industry government academia media consumer